Guarding the Green: Pathways to Stomatal Immunity

Integration of signaling pathways in stomatal development.

Stomata regulate carbon dioxide and water vapor exchange between the plant leaf and the atmosphere. Thus, they represent a critical control point not only for overall photosynthetic efficiency and water balance in the plant, but also for global carbon and water cycling. Stomatal development and function depend upon a variety of exogenous and endogenous signals, including light, carbon dioxide, ...

Guarding Art Galleries by Guarding Witnesses

Let P be a simple polygon. We define a witness set W to be a set of points such that if any (prospective) guard set G guards W , then it is guaranteed that G guards P . We show that not all polygons admit a finite witness set. If a finite minimal witness set exists, then it cannot contain any witness in the interior of P ; all witnesses must lie on the boundary of P , and there can be at most o...

Guarding the Body

Guarding the Gate

BACKGROUND Failed treatment trials are common in major depressive disorder and treatment-resistant depression, and remotely performed multifaceted, centralized structured interviews can potentially enhance signal detection by ensuring that enrolled patients meet eligibility criteria. METHODS We assessed the use of a specific remote structured interview that validated the diagnosis, level of t...

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

RORγt is the key transcription factor controlling the development and function of CD4+ Th17 and CD8+ Tc17 cells. Across a range of human tumors, about 15% of the CD4+ T cell fraction in tumor-infiltrating lymphocytes are RORγ+ cells. To evaluate the role of RORγ in antitumor immunity, we have identified synthetic, small molecule agonists that selectively activate RORγ to a greater extent than t...